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Half-life ~30 min plasma half-life reported in rat models (subcutaneous administration)
The most common side effects include: Flu-like symptoms Headache Irritability Anxiety Nausea Itching and hives Some patients report their body reactions to the injection site, like pain, redness, and swelling
Nevertheless, as these models allow controlling the medium flow, dynamic BBB models were successfully applied for the investigation of the ischemia-induced injury (Cucullo et al., 2008) and antiepileptic drugs (Cucullo et al., 2007)
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