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Preclinical data show that GLP-1and by extension GLP-1R agonistscan modulate macrophage polarization: in vitro treatment of macrophages with GLP-1 reduced M1-specific markers (e.g., Inducible Nitric Oxide Synthase (iNOS), TNF-, IL-6) and increased M2-associated markers (e.g., IL-10, CD163, CD204) via signaling pathways involving increased signal transducer and activator of transcription 3 (STAT3) activation, thereby promoting an anti-inflammatory M2 phenotype [51]

doi: 10.3892/etm.2022.11536 168 PohlKMoodleyPDhandaA

Introduction to Semanat Injection (Semaglutide) 1.1 Overview of Semaglutide as a GLP-1 Receptor Agonist Semanat Injection contains semaglutide, a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist engineered to emulate endogenous incretin hormones

Its important to follow the recommended dosage and consult with a healthcare provider if you have any concerns

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