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A separate Phase 2 trial in type 2 diabetes evaluated retatrutide against placebo and an active comparator, reporting clinically meaningful reductions in HbA1c together with weight loss across the dose range

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Together they reduce appetite, smooth post-meal blood sugar spikes, and nudge the body to use more stored fat for energy

Nutrition and exercise interventions to improve body composition for persons with overweight or obesity near retirement age: a systematic review and network meta-analysis of randomized controlled trials