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The authors also revealed the mechanism: lactate is converted to lactyl-CoA and then transferred to histone lysine residues by a lactyl-transferase

Evstratova et al., 2013

As description indicates in previous work, under conditions with high levels of reactive oxygen molecules, estrogens undergo processing by specific enzymes such as CYP1B1 into forms called 4-hydroxyestrogens that show high reactivity, and these then undergo further oxygen reactions into molecules called quinones

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