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How GLP-1s Work in the Body Slow gastric emptying (food stays in the stomach longer) Increase satiety signals to the brain Reduce appetite and overall intake Improve insulin response and glycemic control While these effects support metabolic health, slower digestion is also what sets the stage for GI symptoms, including reflux. Digestive Impact of GLP-1s: What the Research Shows Increased Upper GI Symptoms One of the most consistent findings across GLP-1 clinical trials is the high rate of gastrointestinal side effects

Some patients and healthcare professionals have reported new or worsening depression, anxiety, or suicidal thoughts following initiation of GLP-1 agonist therapy

Guirguis A, Chiappini S, Papanti PG, Vickers-Smith R, Harris D, Corkery JM, et al

For time-to-event outcomes, weighted cumulative incidence curves were generated and log-rank tests and Cox proportional-hazards (Cox-PH) regressions were conducted (proportional-hazards assumptions were met in these models)