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Clinical data suggests yes

doi: 10.1210/en.2012-2124 72 McLeanBAWongCKCampbellJEHodsonDJTrappSDruckerDJ

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Weight loss outcomes illustrate these differences clearly: berberine supplementation typically results in 24 pounds of weight loss over several months, while GLP-1 therapy produces an average of 1520 pounds or more within the same timeframe in clinical populations

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