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Methionine in turn is required for the synthesis of S-adenosylmethionine, a methyl group donor used in many biological methylation reactions, including the methylation of a number of sites within DNA, RNA, and proteins ( Figure 1 ) (3)

Methylcobalamin provides immediate bioavailability without requiring metabolic conversion, making it theoretically superior

It exhibits an IC 50 of approximately 1 M for NNMT inhibition 4 , with favorable pharmacokinetic properties

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