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The competitive IRAP inhibitor 23 (HA08) enhances the numbers of dendritic spines in hippocampal cell cultures and HA08 treatment resulted in an increasing number of stubby and mushroom-like spines, a morphology typically associated with mature spines, which are believed to have strengthened synaptic connectivity

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In previously untrained adults, 10 weeks of resistance training raised muscle NAD+ by up to 127% (and a related molecule, NADH, by 99%), alongside improvements in the enzymes and proteins that manage NAD+, in a controlled trial

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