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That gap is where the more interesting evidence sits
An overview of acetic acid ulcer modelsthe history and state of the art of peptic ulcer research
There's a decent clinical backing for the moisturizing claims: a small controlled study found that pairing HJE with glycerin lowered transepidermal water loss significantly than glycerin alone (and this effect lasted up to 24 hours)
Patients typically need a BMI of 30 or higher, or a BMI of 27 with weight-related conditions, to qualify, but providers assess the full health picture, including medication interactions and contraindications, before prescribing
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