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The investigators attributed the difference to the more rapid clearance of IGFBP-bound native IGF-1 versus the more sustained free-ligand exposure with the LR3 analog

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14.4 Cardiovascular Outcomes Trial of RYBELSUS in Adult Patients with Type 2 Diabetes Mellitus and High Risk of Having a Cardiovascular Event Trial 7 [Semaglutide Cardiovascular Outcomes Trial (SOUL), NCT03914326] was a randomized, double-blind, parallel-group, placebo-controlled trial