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They are indicated for patients when a prescribing practitioner determines that the compounded preparation produces a significant difference for their patient compared to an FDA-approved product

They are stating that the medication will maintain at least 90% of its labeled potency and meet all quality specifications (sterility, pH, particulate matter) through that date, assuming proper storage

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For example, chronic kidney disease was strongly correlated with heart failure, while it was negatively correlated with metformin usage