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Wang, Li et al., 2014)

doi: 10.1038/s41598-020-71847-5 147 SantosSCFortesGACamargoLTCamargoAJFerriPH

Furthermore, these compounds stabilize enzyme protein conformations, upregulate the transcription and expression of SOD, CAT, and GSH-Px genes, and enhance enzymatic activity to eliminate ROS

On the one hand, they can repair the integrity of the damaged intestinal barrier and promote the enrichment and metabolic activity of protective flora (such as Akkermansia and Lactobacillus ), thereby down-regulating the low-grade chronic inflammation in the whole body and local joints through the gut-joint axis. On the other hand, they can directly inhibit the iron-dependent lipid peroxidation cascade reaction in chondrocytes (such as regulating the GPX4, NRF2 pathways and the expression levels of proteins implicated in iron metabolism) to block or delay the ferroptosis of chondrocytes

10.1523/jneurosci.4694-06.2007 144 ItohT.BeesleyJ.ItohA.CohenA