This coordinated activation allows calcium to flow into the neuron, a fundamental process that drives synaptic plasticity, long-term potentiation, learning, and memory formation
J Am Coll Cardiol 47(1):98107 Zeppenfeld K, Tfelt-Hansen J, de Riva M, Winkel BG, Behr ER, Blom NA, Charron P, Corrado D, Dagres N, de Chillou C, Eckardt L, Friede T, Haugaa KH, Hocini M, Lambiase PD, Marijon E, Merino JL, Peichl P, Priori SG, Reichlin T, Schulz-Menger J, Sticherling C, Tzeis S, Verstrael A, Volterrani M (2022) 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death
In particular, lithium inhibits glycogen synthase kinase 3, 440 which translates in an increase of the density and complexity of astrocytes in the animal models of depression
Glutathione helps in skin pigment production by inhibiting tyrosine which is involved in production of melanin
Glutathione levels are also found to be decreased in central nervous system disorders (such as Alzheimer disease and Parkinson disease), autism, cardiovascular system disorders (atherosclerosis), peripheral vascular disorders, diabetes and its complications, liver disease, acquired immunodeficiency syndrome/human immunodeficiency virus, and chronic obstructive pulmonary diseases
