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The human data is almost nonexistent

Jabbour E, Verstovsek S, Gandhi V, Cortes J, Giles F, OBrien S, Plunkett W, Garcia-Manero G, Kantarjian H, Andreeff M

The protocol works in three phases: remove the cause, accelerate the turnover of pigmented cells through controlled exfoliation, and regulate melanin production at the enzymatic level with targeted actives

4.2 Allergic asthma and allergic rhinitis An in vitro model of allergic airway inflammation, BEAS-2B human bronchial epithelial cells, were pre-treated with BBR (1 M) and activated, resulting in significant inhibition of IL-6 and CC motif chemokine ligand (CCL)-11 secretion, possibly through suppression of STAT6 signaling, without affecting cell viability [53]

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