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Science Translational Medicine, 9(404), eaan0972

Mutualisms and aquatic community structure: the enemy of my enemy is my friend

486 The axon damages caused by SARM1 or NMNAT2 can be restored by increasing NAD + synthesis, like over-expressing the NMNAT2 enzyme

Its mechanism of action has been attributed to the suppression of proteolytic bacteria, by favoring an increase in acidophilic bacteria (e.g., Lactobacillus) and ammonia ion uptake, thanks to the acidification of the content of the colon (the increase in bowel movement rhythm and osmotic effect due to reduced pH) and bacterial nitrogen metabolism alteration, stimulating the use of ammonia by those bacteria for protein synthesis.47 All those mechanisms explain its efficacy.48,49 A series of randomized clinical trials (RCTs),5053 as well as observational studies, have shown the benefit of lactulose compared with the absence of therapy, albeit there are no truly double-blind studies, given that it is extremely difficult to blind the laxative effect and the typical sweet taste of lactulose

Sunal, E