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Several clinical trials implemented a combination of semaglutide treatments with sulfonylurea, sitagliptin, basal insulin, metformin, or other antidiabetic drugs (Table 3)

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A higher subcutaneous dose of semaglutide (7.2 mg weekly)93 is currently under investigation in a Phase III clinical trial

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Nevertheless, when analyses were adjusted for BMI, level of physical activity, number of somatic comorbidities, smoking status and alcohol use, results were substantially unchanged