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Two Forms: Microsomal (mEH) vs Soluble (sEH) There are two main forms of epoxide hydrolase with different locations, substrates, and biological roles

It is known that individuals with an anatomical predisposition (disc at risk), whether or not they are taking a GLP-1 agonist, are at highest risk of developing NAION, the updated PI now reads

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Emergence of highly effective GLP-1 agonists, such as Novos semaglutide (Ozempic, Wegovy, and Rybelsus) and liraglutide (Saxenda), and Lillys tirzepatide (Mounjaro) has completely transformed the market for weight loss and diabetes 2

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