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(iii) glutamine starvation leads to granulocyte colony stimulating factor (G-CSF) and granulocyte macrophage colony stimulating factor (GM-CSF) expression and subsequent MDSCs development [196], implying that glutamine supplementation might enhance antitumor immunity after the impairment of MDSCs development

Collectively, these results provide robust evidence that targeting HNF4 enhances ferroptosis-mediated tumor suppression in vivo

doi: 10.1002/ijgo.v156.3 188 ShowellMGMackenzie-ProctorRJordanVHartRJ