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Our findings suggest that primary care providers could consider prescribing phentermine to patients who have discontinued GLP-1 medications, especially if they lost less than 20 pounds while on the GLP-1 medication, Kersten Bartelt, RN, a clinician at Epic Research, told Healio

Oral peptides face challenges from stomach acid and digestive enzymes

At these concentrations, the GLP-1 receptor activation is sufficient to engage anti-inflammatory pathways without triggering the gastrointestinal side effects that make full-dose therapy difficult for many patients

Both matter

Limitations Despite their promise, several limitations exist