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Asthma symptoms characteristically worsen overnight, with peak airway obstruction and hyperreactivity occurring in the early hours of the morning ( atque nocte magis, quam die [more at night than in the day] ( Among circadian-regulated hormones, melatonin is of particular interest

After this first work, many other devices have been developed to mimic lungs by different research groups finding application in disease modeling, toxicology studies and drug testing (89, 124129)

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