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Secondly, studies applying pair-fed and pair-weighed controls, as well as studies in ZDF rats, which are insensitive to amylin receptor mediated weight loss [6], have documented glucose regulatory capacities beyond what is observed with weight loss [12, 17]

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Pfizer recently announced it decided to discontinue clinical trials of its oral GLP-1 medication for weight loss, called danuglipron, after a study participant experienced a liver injury that was potentially linked to the experimental drug

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