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The combination of fever, jaundice, and right upper quadrant pain (Charcot's triad) suggests cholangitis, a medical emergency requiring immediate care

Once complexed by haem-targeting proteins or xenosiderophores, a set of TonB-dependent transporters (TBDTs) are required to transport the haem/iron into the periplasmic space, followed by transport across the inner membrane by ATP-binding cassette (ABC) transporters (Sgheiza et al., 2017)

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