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SURMOUNT-1: Weight Loss Without Diabetes SURMOUNT-1 (N=2,539) enrolled adults with obesity but without diabetes, isolating the non-glycemic weight mechanisms [22]

Can be done with weights, resistance bands, or bodyweight exercises

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The CV benefits of the SGLT2 inhibitor on HF and CV death (primarily driven by HF) are observed with months and most likely are hemodynamically driven (simultaneous reduction in preload and afterload), while those of GLP-1s on MACE take 12 to 16 months to be seen and most likely are related to the drugs antiatherogenic effects

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