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for instance, H3K18la-mediated modification upregulates pro-hypertrophic genes (e.g., ANP, BNP, and -MHC) [139], while Snail1 lactylation activates TGF-/Smad2 signaling to promote aggressive interstitial fibrosis [140]

10.1016/j.phymed.2024.155489 147 ShiX.WuH.LiuY.HuangH.LiuL.YangY.et al (2022)

People with problems absorbing nutrients due to Crohns or inflammatory bowel disease, celiac disease, pancreatic disease, or weight loss surgery may need to take B12 in different forms that bypass the gut, like injections or sublingual (under the tongue) supplements