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However, such associations do not establish causality, particularly given the many uncharacterized variations and confounding factors of zygosity and genetic linkage 5,7

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Treatment usually begins with a lower dose (0.25 mg weekly for four weeks) to minimise gastrointestinal side effects rather than for glycaemic control, with gradual increases to 0.5 mg and potentially 1 mg or 2 mg based on individual response and tolerability

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