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COMT o-methylates catechol oestrogen metabolites and mediates their detoxification, and it is plausible that the activity of this enzyme is inhibited by the accumulation of the cysteine precursor homocysteine

doi: 10.3389/fphar.2020.00313 Received 18 July 2019 Accepted 03 March 2020 Published 11 March 2020 Volume 11 - 2020 Edited by Rolf Teschke, Hospital Hanau, Germany Reviewed by Hartmut Jaeschke, University of Kansas Medical Center Research Institute, United States

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In healthy cells, p53 activation can initiate DNA repair or apoptosis depending on damage severity

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