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Many patients notice that reflux symptoms decrease significantly once their stomachs adjust to semaglutide's effectsusually within 4-6 weeksand they can gradually reintroduce trigger foods in small amounts

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Appetite suppression continues at the same level, but metabolic rate has adjusted to the new body weight, and caloric expenditure matches the reduced intake

The typical escalation is 0.25 mg for weeks 1-4, then 0.5 mg for weeks 5-8, followed by 1 mg for weeks 9-12, and potentially up to 2.4 mg as a maintenance dose