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Concurrently, Furthermore, extensive research suggests that OS may impact cognitive function through various pathways, such as directly damaging parvalbumin-expressing interneurons (PVIs) (Schiavone et al., 2009), hindering oligodendrocyte precursor cell (OPC) proliferation and myelin formation in the prefrontal cortex (PFC) ( 2.2 Oxidative stress in major depressive disorder According to the World Health Organization (WHO), MDD was the fourth leading cause of disability worldwide and was predicted to rise to second by 2020