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Common symptoms include: Nausea (affecting 1040% of patients) Vomiting Diarrhoea Constipation Abdominal discomfort or pain Reduced appetite These effects are usually mild to moderate and tend to diminish over several weeks as the body adjusts to the medicine

[3][4] Phase 2 data provide the primary published evidence base at the time of writing

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60 A recent systematic review found that there is little evidence for a physiologically relevant cephalic phase insulin response, although more than half of the studies examined documented its presence

Additional File 8 Fig