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Safety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, double-blind, randomised, placebo-controlled trial

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Children with high excretion of toxic metals (arbitrarily defined as above Doctor's Data reference range, defined as the top 95% for typical children who are not undergoing chelation therapy) were allowed to continue on to Phase 2