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Notably, discontinuation is associated with weight regain and partial or complete reversal of improvements in cardiometabolic risk factors, including inflammatory markers, blood pressure, lipid profile, and blood glucose levels

8 BMI: At baseline, mean BMI was 38.6 (4.7) kg/m 2 in the placebo arm and 37.6 (7.9) kg/m 2 in the exenatide arm

It has recently been shown that GLP-1R neurons in the dorsomedial hypothalamic nucleus regulate pancreatic activity by affecting the dorsal motor nucleus of the vagus, specifically lowering blood glucose levels by increasing insulin release (Huang et al., 2022)

Jensen SBK et al

Effects of chromium supplementation on body composition in patients with type 2 diabetes: A dose-response systematic review and meta-analysis of randomized controlled trials