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A GPCR negative feedback model recapitulates fine dynamic responses of wt and tax6 mutants The above experiments position calcium and TAX6/Calcineurin as key components for GPCR inhibition and exact adaptation

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In addition, we tested truncated versions of SNL5 and SNL6 in these assays and found that their conserved N-terminal paired amphipathic helix (PAH) domains are the key interaction sites with HDIP1 (Fig

Front Cell Neurosci