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GlaxoSmithKline cited commercial reasons (poor market uptake compared to Trulicity and Ozempic)

Oxidation: Changes neutral methionine to methionine sulfoxide, which can alter charge or reactivity

People with dry skin may need more hydrating products, while oily or acne-prone skin might benefit from lightweight formulas

More than 5,800 participants are enrolled across studies evaluating retatrutide for: Obesity (co-primary: body weight reduction) Obstructive sleep apnea (co-primary: Apnea-Hypopnea Index change) Knee osteoarthritis (co-primary: WOMAC pain subscale) Cardiovascular and kidney outcomes (TRIUMPH-Outcomes, NCT06383390) TRIUMPH-1 Phase 3 results reported approximately 28% mean body weight reduction at 48 weeks at the highest dose the largest weight loss magnitude reported for any pharmacological obesity intervention in a Phase 3 trial as of 2026

'The question is how we use them most effectively and sustainably within our health system