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The access seems to be not through the bloodbrain barrier but rather through a specialized uptake around the circumventricular organs

GLP-1 is an endogenous insulinotropic hormone secreted from L cells of the small intestine, that participates in the homeostatic regulation of insulin and glucose by activating GLP-1R [21, 22]

A large study by Ohno and colleagues, published in Nature in 2020, found that the risk of developing RA rises with every roughly 5 kg of weight gain or every inch added to your waistline

Best for: fat metabolism support, weight management programs, GLP-1 medication adjunct (semaglutide, tirzepatide), liver health, insulin sensitization

Neurosci Lett 289, 189192