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doi:10.2337/dc20-1521 150

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The parental INS-1 (832/13) cell line was kindly provided by Chris Newgard 40

In type 2 diabetes, they help promote and improve insulin secretion and suppress glucagon in a glucose-dependent way

Constipation is less dose-dependent and can persist, making it a more durable reason for discontinuation in patient reports. Sulfur burps reflect food sitting longer in a slowed stomach. Fatigue ranks second only to nausea in patient forums, although much of it tracks the calorie deficit rather than tirzepatide itself. Fried or fatty foods, coffee, meat, and alcohol can also become less appealing