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Lactylation is a newly discovered type of epigenetic modification found in lysine residue of histone protein by the research group of Zhao in 2019 [94], which can directly regulate gene transcription

NAC provides cysteine, the rate-limiting substrate for GSH production, while alpha-lipoic acid regenerates oxidised glutathione back to its reduced form

Despite its importance, many people are unaware of the symptoms, causes, and treatments related to glutathione deficiency

The consideration of cysteine during these simulations were important, as cytosolic cysteine is the rate limiting amino acid precursor for synthesis of GSH, via the -glutamylcysteine synthetase (GCS) enzyme, and this is a function of its reduced concentration compared to the other precursors, glycine and glutamate

doi: 10.1016/S0009-9120(87)80090-5