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The levels of the oxidative stress indicators MDA and SOD suggested an enhanced oxidation state in the control group, while the opposite trends were observed in the GSH-treated group (Fig

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141 Studies have proven that peripherally injected LPS increases the central and peripheral metabolism of TRP via the KYN pathway by exerting neurotoxic effects, inducing reactivation of microglia and astrocytes in the CNS

Below we have discussed these key factors in detail