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For patients with a baseline BMI 35, discontinuation rates due to adverse events were 8.8% and 12.1% for the 9 mg and 12 mg doses, respectively, compared to 4.8% with placebo. High drop-out rate may explain the difference between the efficacy and treatment regimen estimands: 28.7% vs

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Quantitative PCR (qPCR) was performed using Real-time quantitative PCR kit (TaKaRa, Japan) and an LightCycler 96 system (Roche, Switzerland)

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