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Conversely, exogenous infusion of GLP-1 exhibits potent inhibitory effects of gastric emptying, indicating an enterogastrone mechanism

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Commonly reported side effects include: Nausea, vomiting, and diarrhoea particularly during dose escalation Constipation and abdominal discomfort Decreased appetite and early satiety Injection site reactions (mild and transient) Fatigue, especially in the initial weeks of treatment These gastrointestinal effects are consistent with the GLP-1 mechanism and are generally dose-dependent and transient

It is not permanent damage