Here, we used the US Department of Veterans Affairs databases to build a cohort of people with diabetes who initiated GLP-1RA ( n = 215,970) and compared them to those who initiated sulfonylureas ( n = 159,465), dipeptidyl peptidase 4 (DPP4) inhibitors ( n = 117,989) or sodiumglucose cotransporter-2 (SGLT2) inhibitors ( n = 258,614), a control group composed of an equal proportion of individuals initiating sulfonylureas, DPP4 inhibitors and SGLT2 inhibitors ( n = 536,068), and a control group of 1,203,097 individuals who continued use of non-GLP-1RA antihyperglycemics (usual care)
Whether GLP-1-induced gastroparesis resolves after discontinuing medication remains contentious, with conflicting evidence about permanence
The cells were washed with PBS and incubated with FITC-tagged exendin 939 dissolved in cold PBS at a concentration of 10 M for 30 min at 4 C
Published in September 1992 in the Proceedings of the National Academy of Sciences , Thorens article covered the cloning of the rat GLP-1 receptor located in the beta cells of the pancreas (Thorens)
These include cases of pancreatitis and a potential association with thyroid C-cell tumors in rodent models
