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Metabolic shades of S-D-lactoylglutathione

In animal models, including db/db mice, streptozotocin (STZ)-induced diabetic models, and non-obese diabetic (NOD) mice, renal tissues show increased iron content, elevated levels of MDA and ACSL4 , and reduced GPX4 expression, which are the signature features of ferroptosis (Wang et al., 2020

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Supplemental GSH significantly inhibited activation of NF-B, resulting in a decreased production of DV2 in HepG2 cells

Without a healthy microbiome, pathogenic bacteria like Clostridium difficile increase, leading to gastrointestinal disorders such as diarrhea [19]