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The $150 billion metabolic health opportunity will belong to companies that can combine science, scale, access, and evidence

These can often be managed by adjusting technique or temporarily reducing frequency

doi: 10.1111/nyas.14962 42 SinhaSKatariaAKollaBPThusiusNLoukianovaLL

Discussion The macrovascular complications of T2D include CVD such as coronary artery disease, heart failure (HF) and peripheral artery disease, especially in patients whose diabetes is uncontrolled

It is well appreciated that accumulation of ectopic fat, especially in the liver, can lead to an insulin-resistant state predominantly mediated by negative-feedback interference on insulin signal transduction pathways 79,80