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If TSH rises above target range or symptoms of hypothyroidism emerge (fatigue, cold intolerance, dry skin), your thyroid replacement dose may need to increase

Hu et al., 2025

Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial

Consequently, the effective patent life the actual period during which a drug is sold on the market with patent protection and without generic competition typically averages only 7 to 12 years