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GLP-1s are powerful, naturally-occurring hormones made by your gut that send signals to your brain to decrease your appetite, improve your metabolic system, and regulate your digestion so you can feel full longer and maximize nutrient absorption

This mechanical unloading can translate into meaningful symptom improvement, as supported by the American College of Rheumatology guidelines

Final results stabilize at 24% average

Another practical observation is that many people regain weight once the medication is stopped, suggesting the underlying metabolic drivers may not have been fully addressed