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This assembly subsequently activates caspase-1 through CARD-CARD interactions, thereby completing the NLRP3 inflammasome, which drives immune and inflammatory responses by facilitating the maturation of IL-1 and IL-18 and inducing pyroptosis (62) ( Figure 8 )

Use an insulin syringe (29 to 31 gauge, 0.5 mL or 1 mL)

Global burden of MAFLD, MAFLD related cirrhosis and MASH related liver cancer from 1990 to 2021