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Study: Cardiovascular outcomes of semaglutide and tirzepatide for patients with type 2 diabetes in clinical practice

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Dysregulation of FoxO proteins, including FoxO4, is linked to metabolic diseases such as insulin resistance and type 2 diabetes

A secondary analysis also revealed preserved or improved physical function, with a significant reduction in the prevalence of slow gait speed ( 0.35), including IHTG ( p = 0.88 for PCGrimAge, p = 0.36 for PCDNAmTL), suggesting the IHTG association may be marker-specific to DunedinPACE in this pilot analysis (Fig

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