For peptides, the formation of ice crystals can physically damage the molecules
Querfurth HW, LaFerla FM (2010) Alzheimers disease
While inconvenient, its much lower than the diarrhea reported in up to 30% of people taking prescription injectables, see Wegovy Medication Guide, which also lists 44% rate of nausea
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But besides simply not pooping regularly, constipation from semaglutide and other GLP-1 medications can present as: Fewer than three bowel movements per week Hard, dry, or lumpy stools Straining during bowel movements Feeling of incomplete evacuation Abdominal discomfort or bloating Hard stool followed by watery loose stool Its important to distinguish between occasional constipation (which is common) and chronic constipation , which may require assistance to address the cause