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However, no significant changes were observed in fibrosis scores, although there was a trend toward more patients in the combination and vitamin E groups having improved fibrosis stages than in the placebo group

GSEA is a knowledge-based approach for interpreting genomic profiles based on the gene sets

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It stimulates collagen I and III production, increases elastin by 30%, raises decorin levels (which organizes collagen structure), and modulates matrix metalloproteinases to remodel damaged or disorganized collagen

Purity, concentration, and integrity of RNA was assessed by NanoDrop Spectrophotometer (Thermo Fisher Scientific) and by Eukaryote Total RNA Nano chip analysis on a Bioanalyzer (Agilent Technologies) at the Stanford Protein and Nucleic Acid Facility