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For more severe or persistent symptoms, proton pump inhibitors (PPIs) such as omeprazole or esomeprazole provide the most potent acid suppression and are typically prescribed for an 8-week trial, then stepped down to the lowest effective dose

It evaluated weekly subcutaneous injections of semaglutide 2.0mg and semaglutide 1.0mg as a supplement to metformin and/or sulfonylureas

Similarly, regular physical activity may also play a role in supporting healthy GLP-1 production

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