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Apart from inducing oxidative stress, ROS molecules attack almost every component of the cell and cause further nonspecific damage to surrounding tissues

10.1136/thx.2009.113456 2 AnC.JiaoB.DuH.TranM.ZhouD.WangY

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In 1832, Scottish physician Thomas Aitchison Latta used intravenous infusions of saline solution to treat patients during a cholera epidemic, laying the foundation for modern IV fluid resuscitation